Abstract
Background: 2-phenylethylamine (2-PEA) is an organic neurotransmitter which belongs to a class of biogenic amines that are essential for regulation of cellular development, differentiation and homeostasis. This class of compounds have been reported to cause oxidative stress to neuronal cells in the brain, which have a high oxygen consumption rate, elevated iron content and low antioxidant concentration. 2-phenylethylamine can metabolise into hydroxyl radicals which have been found to be a direct cause of oxidative stress within cells.
Methods: This study has examined the toxicity of 2-phenylethylamine in the yeasts, Saccharomyces cerevisiae and Candida glabrata by examining growth with glucose or ethanol as sources, in the presence of 2-phenylethylamine.
Results: 2-phenylethylamine was found to be inhibitory to all strains of yeast where respiratory function was necessary, while growth where glucose was the carbon source was unaffected. Almost all growth inhibition could be reversed by antioxidants ascorbate and glutathione, indicating oxidative stress was the likely cause of toxicity through 2-PEA or one of its metabolites.
Conclusion: Yeast studies show that the biogenic amine, 2-phenylethylamine, targets respiratory function and that the inhibition can be reversed alleviated by the addition of glutathione or ascorbate.
Keywords: 2-phenylethylamine, ascorbic acid, glutathione, mitochondrial respiratory function, reactive oxygen, yeast.
Current Bioactive Compounds
Title:Inhibition of Respiration in Yeast by 2-Phenylethylamine
Volume: 14 Issue: 1
Author(s): Jason A. Phillips and Ian G. Macreadie*
Affiliation:
- School of Science, RMIT University, Bundoora West Campus, P.O. Box 71, Bundoora, Melbourne, Victoria 3083,Australia
Keywords: 2-phenylethylamine, ascorbic acid, glutathione, mitochondrial respiratory function, reactive oxygen, yeast.
Abstract: Background: 2-phenylethylamine (2-PEA) is an organic neurotransmitter which belongs to a class of biogenic amines that are essential for regulation of cellular development, differentiation and homeostasis. This class of compounds have been reported to cause oxidative stress to neuronal cells in the brain, which have a high oxygen consumption rate, elevated iron content and low antioxidant concentration. 2-phenylethylamine can metabolise into hydroxyl radicals which have been found to be a direct cause of oxidative stress within cells.
Methods: This study has examined the toxicity of 2-phenylethylamine in the yeasts, Saccharomyces cerevisiae and Candida glabrata by examining growth with glucose or ethanol as sources, in the presence of 2-phenylethylamine.
Results: 2-phenylethylamine was found to be inhibitory to all strains of yeast where respiratory function was necessary, while growth where glucose was the carbon source was unaffected. Almost all growth inhibition could be reversed by antioxidants ascorbate and glutathione, indicating oxidative stress was the likely cause of toxicity through 2-PEA or one of its metabolites.
Conclusion: Yeast studies show that the biogenic amine, 2-phenylethylamine, targets respiratory function and that the inhibition can be reversed alleviated by the addition of glutathione or ascorbate.
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Cite this article as:
Phillips A. Jason and Macreadie G. Ian*, Inhibition of Respiration in Yeast by 2-Phenylethylamine, Current Bioactive Compounds 2018; 14 (1) . https://dx.doi.org/10.2174/1573407213666161207115458
DOI https://dx.doi.org/10.2174/1573407213666161207115458 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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Antioxidants: Unveiling their Power in Health and Disease
Antioxidants have captured significant interest for decades due to their potential role in preventing chronic diseases. These molecules combat free radicals and unstable molecules that damage cells and contribute to the development of conditions like metabolic diseases, heart disease, cancer, and neurodegenerative diseases. This thematic issue will explore the cutting-edge ...read more
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The Special Issue "Bioactive Compounds: Discovery, Design, Development, and Target Identification" aims to bring together innovative research and critical reviews on bioactive molecules that show therapeutic potential across diverse diseases. Discovery of novel bioactive compounds will focus on uncovering new molecules from natural or synthetic sources, expanding the library of ...read more

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