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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Research Article

Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent

Author(s): Denish Viradiya, Sheefa Mirza, Faraz Shaikh, Rajesh Kakadiya*, Anand Rathod, Nayan Jain, Rakesh Rawal* and Anamik Shah*

Volume 17 , Issue 7 , 2017

Page: [1003 - 1013] Pages: 11

DOI: 10.2174/1871520616666161206143251

Price: $65

Abstract

Aims: A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and colorectal adenocarcinoma Caco-2 cell lines using the MTT assay.

Method: Among these compounds, 7b, 7d, 7e, and 7f exhibited potent anticancer activity against the cell lines tested. The cytotoxicity of the synthesized derivatives was compared to standard drugs (carboplatin, gemcitabine, and daunorubicin).

Result: Thus, synthesized 1,4-dihydropyridines can be considered as the encouraging molecules for further drug development as anticancer agents.

Keywords: Anticancer activity, antipoliferative activity, benzylpyridinium salt, 1, 4-dihydropyridine, MTT assay.

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