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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities

Author(s): Arthur Ladeira Macedo, Thais Carvalho Costa dos Santos, Alessandra Leda Valverde, Davyson de Lima Moreira and Thatyana Rocha Alves Vasconcelos*

Volume 17 , Issue 8 , 2017

Page: [693 - 720] Pages: 28

DOI: 10.2174/1389557516666161130094826

Price: $65

Abstract

Background: The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD).

Objective: Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics.

Results: The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.

Keywords: Biological activity, extraction, isolation, natural products, neolignans, Piper, Piperaceae.


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