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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review

Author(s): Sonika Batra and Ravi Bhushan*

Volume 24, Issue 8, 2017

Page: [758 - 780] Pages: 23

DOI: 10.2174/0929867323666161129093052

Price: $65

Abstract

(S)-Naproxen (Npx), an α-aryl propionic acid derivative, belongs to the class of Non-Steroidal Anti-Inflammatory Drugs and is easily available in pure (S)-form. (S)-Npx has been used as a chiral selector for chromatographic separation of a variety of racemates, using both direct and indirect methods, and has been found to be useful and successful as a basic chiral moiety. This review article describes methods for enantioseparation of (RS)-Npx, development of chiral stationary phases based on (S)-Npx and preparation of novel chiral derivatizing reagents synthesized from (S)-Npx along with their application for enantioseparation of several pharmaceutically important racemates.

Keywords: (S)-Naproxen, liquid chromatography, chiral derivatizing reagents, chiral stationary phase, enantioseparation, racemic pharmaceuticals.

Graphical Abstract

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