Natural Products with Antiplatelet Action

Title:Natural Products with Antiplatelet Action

Volume: 23 Issue: 8

Author(s): Gabriela Elisa Hirsch, Paulo Ricardo Nazario Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi and Jonatas Zeni Klafke*

Affiliation:

• Programa de Pós-Graduação em Atenção Integral à Saúde, Universidade de Cruz Alta, Campus Universitário Dr. Ulysses Guimarães - Rodovia Municipal Jacob Della Méa, Km 5.6 - Parada Benito, 98020-290 Cruz Alta, RS,Brazil

Keywords: Platelet aggregation, medicinal plants, phytochemicals, agonists, antiaggregatory activity, cardiovascular diseases.

Abstract: Background: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation. These mechanisms have been widely studied and discussed because they are inhibited by the use of medicinal plants in complementary and alternative medicine, thus reducing platelet aggregation.

Results: Of the main plants discussed in this review, which have antiplatelet activity, some include saffron, garlic, green tea, St. John's wort, ginger, ginkgo biloba, ginseng, and guavirova. These herbal medicines have phytochemical components, which are directly related to the antiplatelet activity of the plant, such as flavonoids, curcumins, catechins, terpenoids, polyphenols, and saponins. While the majority of the medicinal plants mentioned here were native to the Asian continents, some are distributed worldwide, and found to a smaller extent throughout the American continent, European continent, Mediterranean, African continent, and the Middle East.

Conclusion: This review showed that several plants and/or compounds exhibit anti-platelet activity, and are therefore potential research targets for developing drugs to treat diseases related to aggregation disorders.

Cite this article as:

Hirsch Elisa Gabriela, Viecili Ricardo Nazario Paulo, de Almeida Spring Amanda, Nascimento Sabrina, Porto Garcez Fernando, Otero Juliana, Schmidt Aline, da Silva Brenda, Parisi Migliorini Mariana and Klafke Zeni Jonatas*, Natural Products with Antiplatelet Action, Current Pharmaceutical Design 2017; 23 (8) . https://dx.doi.org/10.2174/1381612823666161123151611

DOI https://dx.doi.org/10.2174/1381612823666161123151611	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286