Abstract
Matrine-type alkaloids belong to quinolizidine analogues from Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L. possess numerous therapeutic properties and have attracted continuous attention over the past few decades. In order to improve the activities and amplify their applicants, many matrine-type derivatives have synthesized and evaluated for their biological activities in recent years. These structural modifications have resulted in stronger activities and improvement of the pharmacokinetic properties. The structure and activity relation studies based on matrine- type semi-synthetic derivatives have immensely contributed to the understanding of their mechanism of actions and molecular targets. This review mainly summarizes recent progress in the structural modifications of matrine-type alkaloids based on the alteration of C-13 or C-14 position, opening D ring, fusing D ring and structural simplification.
Keywords: Bioactivities, Chinese traditional medicine, matrine, matrine-type alkaloids, sophoridine, structural modifications.
Mini-Reviews in Medicinal Chemistry
Title:Structural Modifications of Matrine-Type Alkaloids
Volume: 18 Issue: 9
Author(s): Xiao-Hua Cai*, Hui Guo*Bing Xie
Affiliation:
- National School of Medicine, Guizhou Minzhu University, Guiyang 550025,China
- College of Pharmaceutical Sciences, Zhejiang Technology University, Hangzhou 310014,China
Keywords: Bioactivities, Chinese traditional medicine, matrine, matrine-type alkaloids, sophoridine, structural modifications.
Abstract: Matrine-type alkaloids belong to quinolizidine analogues from Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L. possess numerous therapeutic properties and have attracted continuous attention over the past few decades. In order to improve the activities and amplify their applicants, many matrine-type derivatives have synthesized and evaluated for their biological activities in recent years. These structural modifications have resulted in stronger activities and improvement of the pharmacokinetic properties. The structure and activity relation studies based on matrine- type semi-synthetic derivatives have immensely contributed to the understanding of their mechanism of actions and molecular targets. This review mainly summarizes recent progress in the structural modifications of matrine-type alkaloids based on the alteration of C-13 or C-14 position, opening D ring, fusing D ring and structural simplification.
Export Options
About this article
Cite this article as:
Cai Xiao-Hua*, Guo Hui*, Xie Bing, Structural Modifications of Matrine-Type Alkaloids, Mini-Reviews in Medicinal Chemistry 2018; 18 (9) . https://dx.doi.org/10.2174/1389557516666161104150334
DOI https://dx.doi.org/10.2174/1389557516666161104150334 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Detection of Tumor Markers with ProteinChip® Technology
Current Pharmaceutical Biotechnology Histone Deacetylases: Anti-Angiogenic Targets in Cancer Therapy
Current Cancer Drug Targets Therapeutic Potential of Natural Compounds that Regulate the Activity of Protein Kinase C
Current Medicinal Chemistry Cetuximab, A Chimeric Anti-Epidermal Growth Factor Receptor Monoclonal Antibody, in Colorectal Cancer Treatment
Current Cancer Therapy Reviews Pathobiology and Prevention of Cancer Chemotherapy-Induced Bone Growth Arrest, Bone Loss, and Osteonecrosis
Current Molecular Medicine Nanotools for the Delivery of Antimicrobial Peptides
Current Drug Targets Anti-Angiogenic Drugs and Biomarkers in Non-Small-Cell Lung Cancer: 'A Hard Days Night'
Current Pharmaceutical Design Antiproliferative and Proapoptotic Effects of Proteasome Inhibitors and their Combination with Histone Deacetylase Inhibitors on Leukemia Cells
Cardiovascular & Hematological Disorders-Drug Targets Clinico-Pathologic and Biologic Predictors of EGFR Inhibitors Activity and Efficacy in Lung and in Colorectal Cancer
Current Signal Transduction Therapy Oxidative DNA Damage and Oxidant/Anti-Oxidant Enzymatic Systems in Carcinogenesis and Cancer Progression
Current Enzyme Inhibition Glucans as Biological Response Modifiers
Endocrine, Metabolic & Immune Disorders - Drug Targets Endogenous Angiogenesis Inhibitors as Therapeutic Agents: Historical Perspective and Future Direction
Recent Patents on Anti-Cancer Drug Discovery Metals and Metal Derivatives in Medicine
Mini-Reviews in Medicinal Chemistry Antitumor Activities of Interleukin-27 on Melanoma
Endocrine, Metabolic & Immune Disorders - Drug Targets Cell Cycle Kinases in Osteosarcoma: Potential for Therapeutic Intervention
Current Pharmaceutical Design Pulmonary and Nasal Anti-Inflammatory and Anti-Allergy Inhalation Aerosol Delivery Systems
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Potential Role of Statins in Re-Endothelialization
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Recent Updates on Biological Activities of Oxadiazoles
Mini-Reviews in Medicinal Chemistry Editorial [Hot Topic: Reprogramming of Normal and Cancer Stem Cells (Guest Editor: Pier Mario Biava)]
Current Pharmaceutical Biotechnology Quantitative Prediction of Glucuronidation in Humans Using the In Vitro- In Vivo Extrapolation Approach
Current Topics in Medicinal Chemistry