Abstract
Background: The p-toluenesulfonyl (tosyl) group is one of the most versatile protecting groups for phenols and alcohols, but its removal requires drastic conditions due to their high stability.
Methods: In the course of reaction, (Et4N)O2 was generated in situ by the phase transfer reaction of KO2 and Et4NBr in dry DMF was subsequently allowed to react with tosyl esters, under microwave irradiation. Results: Tosyl esters were readily deprotected to their corresponding phenols and alcohols. Conclusion: In conclusion, a mild and efficient method for the removal of tosyl protecting group, using in situ generated tetraethylammonium superoxide under microwave irradiation, has been described.Keywords: Deprotection, microwave irradiation, superoxide, tosyl esters.
Graphical Abstract
Call for Papers in Thematic Issues
Microwave Technology: Advancements and Applications in Chemistry, Environment and Food Science
Microwave technology has emerged as a transformative tool in various fields, offering unique opportunities for rapid, efficient, and clean processes. This thematic issue aims to encapsulate the latest research, innovative strategies, and progressive methodologies concerning the application of microwave technology in three main areas: Chemistry: Highlighting the advancements in microwave-assisted ...read more
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