Abstract
Inflammation has been reported in numerous neurodegenerative disorders such as Parkinsons disease, stroke and Alzheimers disease (AD). In AD, the inflammatory response is mainly located to the vicinity of amyloid plaques. Cytokines, such as Interleukin-1 (IL-1), Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-α) and Transforming Growth Factor beta (TGF-β) have been clearly involved in this inflammatory process. Although their expression is induced by the presence of amyloid-beta peptide, these cytokines are also able to promote the accumulation of amyloidbeta peptide. Altogether, IL-1, IL-6, TNF-α and TGF-β should be considered as key players of a vicious circle leading to the progression of the disease.
Keywords: alzheimer disease, inflammation, cytokine
Current Drug Targets
Title: Cytokines in Neuroinflammation and Alzheimers Disease
Volume: 5 Issue: 6
Author(s): Mathias Cacquevel, Nathalie Lebeurrier, Simon Cheenne and Denis Vivien
Affiliation:
Keywords: alzheimer disease, inflammation, cytokine
Abstract: Inflammation has been reported in numerous neurodegenerative disorders such as Parkinsons disease, stroke and Alzheimers disease (AD). In AD, the inflammatory response is mainly located to the vicinity of amyloid plaques. Cytokines, such as Interleukin-1 (IL-1), Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-α) and Transforming Growth Factor beta (TGF-β) have been clearly involved in this inflammatory process. Although their expression is induced by the presence of amyloid-beta peptide, these cytokines are also able to promote the accumulation of amyloidbeta peptide. Altogether, IL-1, IL-6, TNF-α and TGF-β should be considered as key players of a vicious circle leading to the progression of the disease.
Export Options
About this article
Cite this article as:
Cacquevel Mathias, Lebeurrier Nathalie, Cheenne Simon and Vivien Denis, Cytokines in Neuroinflammation and Alzheimers Disease, Current Drug Targets 2004; 5 (6) . https://dx.doi.org/10.2174/1389450043345308
DOI https://dx.doi.org/10.2174/1389450043345308 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Potential Effect of Fluorinated Compounds in the Treatment of Alzheimer’s Disease
Current Pharmaceutical Design Chemistry and Pharmacology of Bioactive Molecule -Coenzyme Q10: A Brief Note
Current Bioactive Compounds Treatment Options in Alzheimer´s Disease: The GABA Story
Current Pharmaceutical Design From Bone to Brain: Human Skeletal Stem Cell Therapy for Stroke
Central Nervous System Agents in Medicinal Chemistry Translational Imaging of Apoptosis
Anti-Cancer Agents in Medicinal Chemistry Advanced Tools of Regenerative Medicine for Neurodegenerative Diseases
Recent Patents on Regenerative Medicine Davunetide: Peptide Therapeutic in Neurological Disorders
Current Medicinal Chemistry Complex Polyamines: Unique Prion Disaggregating Compounds
CNS & Neurological Disorders - Drug Targets Mechanisms of Immune Modulation by Mesenchymal Stromal Cells and Clinical Translation
Current Molecular Medicine Mitochondrial Proteases as Emerging Pharmacological Targets
Current Pharmaceutical Design Antioxidant Activities of Retinoidal Benzimidazole Or Indole Derivatives in In Vitro Model Systems
Current Medicinal Chemistry Editorial (Thematic Issue: An Overwiew on the Chemistry and Biochemistry of Triterpenoids)
Mini-Reviews in Organic Chemistry Induction of Molecular Chaperones as a Therapeutic Strategy for the Polyglutamine Diseases
Current Pharmaceutical Biotechnology Neuronal Nicotinic Receptors and Neuroprotection: Newer Ligands May Help us Understand their Role in Neurodegeneration
Medicinal Chemistry Reviews - Online (Discontinued) Mechanism of Lipid Binding of Human Apolipoprotein E3 by Hydrogen/Deuterium Exchange/Mass Spectrometry and Fluorescence Polarization
Protein & Peptide Letters Pin1: A New Genetic Link between Alzheimer’s Disease, Cancer and Aging
Current Aging Science Traditional Fruits of Kerala: Bioactive Compounds and their Curative Potential in Chronic Diseases
Current Nutrition & Food Science Synthetic Cannabinoid Receptor Agonists and Antagonists: Implication in CNS Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Structural variations and molten globule state in Arisaema helliborifolium lectin under various treatments as monitored by spectroscopy
Protein & Peptide Letters Anti-Inflammatory Treatments for Chronic Diseases: A Review
Inflammation & Allergy - Drug Targets (Discontinued)