Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

Jan      Dusek; Ales      Imramovsky; Karel      Pauk; Radek      Jorda; Eva      Reznickova; Vladimir      Krystof

Abstract

Background: On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties.

Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds.

Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range.

Keywords: Salicylamides, antiproliferative activity, cytotoxic activity, pharmacological activity, amines.

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Letters in Drug Design & Discovery

Title:Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

Volume: 14 Issue: 6

Author(s): Jan Dusek, Ales Imramovsky, Karel Pauk, Radek Jorda, Eva Reznickova and Vladimir Krystof

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Keywords: Salicylamides, antiproliferative activity, cytotoxic activity, pharmacological activity, amines.

Abstract: Background: On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties.

Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds.

Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range.

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Dusek Jan, Imramovsky Ales, Pauk Karel, Jorda Radek, Reznickova Eva and Krystof Vladimir, Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives, Letters in Drug Design & Discovery 2017; 14(6) . https://dx.doi.org/10.2174/1570180813666161020113827

DOI https://dx.doi.org/10.2174/1570180813666161020113827	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X