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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Antimicrobial AApeptides

Author(s): Peng Sang, Yan Shi, Peng Teng, Annie Cao, Hai Xu, Qi Li and Jianfeng Cai

Volume 17, Issue 11, 2017

Page: [1266 - 1279] Pages: 14

DOI: 10.2174/1568026616666161018145945

Price: $65


Antibiotic resistance is one of the biggest public concerns in the 21st century. Host-defense peptides (HDPs) can potentially mitigate the problem through bacterial membrane disruption; however, they suffer from moderate activity and low stability. We recently developed a new class of peptidomimetics termed “AApeptides”. This class of peptidomimetics can mimic the mechanism of action of HDPs, and effectively arrest the growth of multidrug resistant Gram-positive and Gram-negative bacteria. As they are built on unnatural backbone, they are resistant to proteolytic degradation. In this review, we summarize the development of this class of antimicrobial peptidomimetics, and discuss the future perspective on how they can move forward on combating antibiotic resistance.

Keywords: Antibiotic resistance, Host-defense peptides (HDPs), AApeptides, Peptidomimetics, Antimicrobial activity.

Graphical Abstract

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