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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Heterocyclic Antioxidants in Nature: Coumarins

Author(s): Maria J. Matos, Saleta Vazquez-Rodriguez, Andre Fonseca, Eugenio Uriarte, Lourdes Santana and Fernanda Borges

Volume 21, Issue 4, 2017

Page: [311 - 324] Pages: 14

DOI: 10.2174/1385272820666161017170652

Price: $65


Coumarins represent an important family of naturally occurring and/or synthetic oxygen-containing heterocycles, bearing a characteristic benzopyrone framework. These compounds are widely distributed both in human diet and therapeutics. Among other characteristics, several coumarin derivatives proved to have an interesting antioxidant profile. In the current review, an overview of the role of natural coumarins as important antioxidants is presented and discussed. The benefits of antioxidants to prevent chronic diseases is also discussed in the current review. The most common assays performed to evaluate the antioxidant capacity described in this review are related to different reactive oxygen species involved in the oxidative process. Several reaction mechanisms were studied to investigate the antioxidant profile of coumarins. Among them, hydrogen atom transfer (HAT) and single electron transfer transfer (SET), were highly cited. To make the organization of this overview as clear as possible, coumarin derivatives were dived in: simple coumarins; aliphatic, terpenoid and aromaticcontaining coumarins; ring-fused coumarins and ellagic acid derivatives.

Keywords: Natural products, coumarin scaffold, antioxidants, radicals scavenging.

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