Abstract
One of the biggest challenges in the modern medicine and the food industry is to provide chemical agents that, incorporated in the foods, could have some pharmacological properties, but mainly that can protect and preserve our health from oxidative stress, and could be used in clinical treatments against some chronic diseases with minor side effects. In this sense, aporphine alkaloids have been the group of nitrogen compounds more studied in nature, incorporated in many foods and with a wide therapeutic application. Examples such as ()- boldine (12), ()-liridinine (15), (+)-lirinidine (16) and glaucine (24) have been studied for their interesting antioxidant activity and, in case of 24, synthetic modifications have managed to generate derivatives that exhibit more efficient antioxidant activity. Therefore, clinical treatment against oxidative stress-related diseases, such as Parkinson´s disease, anticancer, antinociceptive, therapeutic applications among other mentioned in this review, gives the possibility of using these aporphine alkaloids of low cytotoxicity as an excellent alternative in the development of new therapeutic patterns using the duplicity; biologically active ingredient-antioxidant.
Keywords: Aporphines, oxoaporphines, antioxidant, free radical scavengers, oxidative stress, Parkinson's disease, anticancer, antinociceptive.
Current Organic Chemistry
Title:Aporphine Alkaloids and their Antioxidant Medical Application: From Antineoplastic Agents to Motor Dysfunction Diseases
Volume: 21 Issue: 4
Author(s): Seyed M. Nabavi, Eugenio Uriarte, Jose A. Fontenla, Luca Rastrelli and Eduardo Sobarzo-Sanchez
Affiliation:
Keywords: Aporphines, oxoaporphines, antioxidant, free radical scavengers, oxidative stress, Parkinson's disease, anticancer, antinociceptive.
Abstract: One of the biggest challenges in the modern medicine and the food industry is to provide chemical agents that, incorporated in the foods, could have some pharmacological properties, but mainly that can protect and preserve our health from oxidative stress, and could be used in clinical treatments against some chronic diseases with minor side effects. In this sense, aporphine alkaloids have been the group of nitrogen compounds more studied in nature, incorporated in many foods and with a wide therapeutic application. Examples such as ()- boldine (12), ()-liridinine (15), (+)-lirinidine (16) and glaucine (24) have been studied for their interesting antioxidant activity and, in case of 24, synthetic modifications have managed to generate derivatives that exhibit more efficient antioxidant activity. Therefore, clinical treatment against oxidative stress-related diseases, such as Parkinson´s disease, anticancer, antinociceptive, therapeutic applications among other mentioned in this review, gives the possibility of using these aporphine alkaloids of low cytotoxicity as an excellent alternative in the development of new therapeutic patterns using the duplicity; biologically active ingredient-antioxidant.
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Nabavi M. Seyed, Uriarte Eugenio, Fontenla A. Jose, Rastrelli Luca and Sobarzo-Sanchez Eduardo, Aporphine Alkaloids and their Antioxidant Medical Application: From Antineoplastic Agents to Motor Dysfunction Diseases, Current Organic Chemistry 2017; 21 (4) . https://dx.doi.org/10.2174/1385272820666161017165735
DOI https://dx.doi.org/10.2174/1385272820666161017165735 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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