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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Arjunolic Acid: A Promising Antioxidant Moiety with Diverse Biological Applications

Author(s): Arun Nanda, S. H. Ansari and Sarita Khatkar

Volume 21 , Issue 4 , 2017

Page: [287 - 293] Pages: 7

DOI: 10.2174/1385272820666161017164404

Price: $65

Abstract

Arjunolic acid (AA) is a triterpenoid saponin isolated mainly from Terminalia arjuna bark. Arjunolic acid is associated with the various important physiological functions viz. antioxidant, antimicrobial, cardioprotective, hepatoprotective, and plays important role in supramolecular chemistry, etc. Arjunolic acid exhibits important function in maintaining the level of various antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx), level of cellular metabolites, reduced glutathione (GSH), oxidized glutathione (GSSG) and thereby reduces the oxidative stress. Its protective effect on liver, pancreas and kidney has also been the key property of arjunolic acid. Hence, arjunolic acid has potential to treat various disorders and this review may provide valuable information about arjunolic acid.

Keywords: Oxidative stress, arjunolic acid, Terminalia arjuna, reactive oxygen species (ROS), reactive nitrogen species (RON).

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