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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Garlic for Cardiovascular Disease: Prevention or Treatment?

Author(s): Feras Q. Alali*, Tamam El-Elimat, Lila Khalid, Reema Hudaib, Tuqa Saleh Al-Shehabi and Ali H. Eid*

Volume 23, Issue 7, 2017

Page: [1028 - 1041] Pages: 14

DOI: 10.2174/1381612822666161010124530

Price: $65


Cardiovascular disease (CVD) is the leading cause of global mortality with a substantial economic impact. The annual deaths are expected to increase in the next decade. An array of dietary supplements is being used by people worldwide to ameliorate cardiovascular risk factors. Garlic (Allium sativum L.), a top-selling herbal dietary supplement, is renowned for its wide range beneficial effects, particularly in the treatment and prevention of CVD. This review aims to present a thorough discussion of the available evidence-based data which support the use of garlic in the treatment or prevention of cardiovascular diseases, including atherosclerosis, hypertension, and hyperlipidemia. The molecular mechanisms underlying these effects are dissected as well. This review supports the notion that garlic has the potential to treat mild hypertension, to decrease hypercholesterolemia, and to prevent atherosclerosis. More clinical studies are essential to unequivocally understand the mechanisms underlying treatment or prevention of these cardiovascular conditions.

Keywords: Cardiovascular disease, atherosclerosis, hypertension, thrombosis, hyperlipidemia, garlic, Allium sativum, herbal medicine.

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