Abstract
Background: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.
Results: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers. Conclusion: Here, main functions and its known inhibitors were summarized.Keywords: Cancer, ε-amino, HATs, HDACs, histone acetyltransferase, inhibitor, Tip60.
Mini-Reviews in Medicinal Chemistry
Title:Tip60: Main Functions and Its Inhibitors
Volume: 17 Issue: 8
Author(s): Xiaoli Zhang, Jiyong Wu and Yepeng Luan*
Affiliation:
- Department of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao, Shandong Province,China
Keywords: Cancer, ε-amino, HATs, HDACs, histone acetyltransferase, inhibitor, Tip60.
Abstract: Background: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.
Results: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers. Conclusion: Here, main functions and its known inhibitors were summarized.Export Options
About this article
Cite this article as:
Zhang Xiaoli, Wu Jiyong and Luan Yepeng*, Tip60: Main Functions and Its Inhibitors, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557516666160923125031
DOI https://dx.doi.org/10.2174/1389557516666160923125031 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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