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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Cocoa Polyphenols: Chemistry, Bioavailability and Effects on Cardiovascular Performance

Author(s): Laura Dugo, Giusy Tripodo, Luca Santi and Chiara Fanali*

Volume 25 , Issue 37 , 2018

Page: [4903 - 4917] Pages: 15

DOI: 10.2174/0929867323666160919094339

Price: $65


This review gives an overview of the phenolic compounds composition of cocoa beans and their modification during manufacturing processes to the final products. Recently published papers dealing with the qualitative and quantitative analysis of the different classes of cocoa phenolic compounds will be discussed. Modifications of the qualitative profile and amount of phenolic compounds in cocoa after the main processes of production chain, fermentation, drying, roasting, and alkalization, will be described.

The second part will focus on some of the biological effects described for cocoa phenolic compounds in vitro and in vivo. In particular, the effects of cocoa flavanols on cardiovascular health and endothelial function have been extensively investigated over the last decades, with interesting results from nutritional intervention trials and molecular studies. A few recent updates on the role of cocoa and chocolate consumption on sport performances will be reported.

Keywords: Polyphenols, cocoa beans, flavanols, processing, cardiovascular diseases, nitric oxide, blood pressure.

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