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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Is Mania the Hypertension of the Mood? Discussion of A Hypothesis

Author(s): Zoltan Rihmer, Xenia Gonda and Peter Dome

Volume 15, Issue 3, 2017

Page: [424 - 433] Pages: 10

DOI: 10.2174/1570159X14666160902145635

Price: $65


Beyond both being biphasic/bidirectional disorders (hypo)mania and essential hypertension share a surprising number of similarities and an overlap between their genetics, biological background, underlying personality and temperamental factors, precipitating factors, comorbidity and response to treatment, indicating a possibly partially shared biological background. Based on theoretical knowledge, similarities related to characteristics, manifestation and course, and the results of pharmacological studies related to the effects and side effects of pharmacotherapies used in the treatment of these two distinct disorders, the authors outline a hypothesis discussing the similar origins of these two phenomena and thus mania being the hypertension of mood in memory of Athanasios Koukopoulos, one of the greatest researchers and theoreticists of mania of all time.

Keywords: Bipolar disorder, comorbidity, hypertension, mania, temperament, underlying mechanisms.

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