Melatonin and Respiratory Diseases: A Review

Title:Melatonin and Respiratory Diseases: A Review

Volume: 17 Issue: 4

Author(s): Solomon Habtemariam, Maria Daglia, Antoni Sureda, Zeliha Selamoglu, Mehmet Fuat Gulhan and Seyed Mohammad Nabavi

Affiliation:

• Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.,Iran

Keywords: Anti-inflammatory, Antioxidant, Lung disease, Melatonin, Pulmonary disease, Respiratory disorders.

Abstract: Melatonin is an indoleamine with potent multifunctional biological and pharmacological effects, both receptor dependent and receptor-independent effects, including antioxidant, anticancer, antitumor, anti-inflammatory, anti-aging, anti-diabetic, antiviral, neuroprotective activities. Melatonin mitigates tissue injury via modification of abnormalities in redox status and other biochemical markers. At the molecular level, the biological and pharmacological activities of melatonin are attributed to the inhibition of nuclear factor-κappa beta (NF-κβ), c-Fos over expression and down-regulation of matrix metalloproteinases-3 (MMP-3), which are regulators of pro-inflammatory and pro-fibrotic cytokines. There are numerous scientific reports on the therapeutic potential of melatonin in treatment of asthma, respiratory diseases for infections, chronic obstructive pulmonary disease, lung cancer, pleural cavity diseases, as well as vascular pulmonary disease. In the present communication, we systematically review the therapeutic potential of melatonin in the treatment of respiratory diseases along with its molecular mechanism of actions.

Cite this article as:

Habtemariam Solomon, Daglia Maria, Sureda Antoni, Selamoglu Zeliha, Gulhan Fuat Mehmet and Nabavi Mohammad Seyed, Melatonin and Respiratory Diseases: A Review, Current Topics in Medicinal Chemistry 2017; 17(4) . https://dx.doi.org/10.2174/1568026616666160824120338