Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors

Title:Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors

Volume: 17 Issue: 4

Author(s): Mina Saeedi, Abbas Hadjiakhondi, Seyed Mohammad Nabavi and Azadeh Manayi

Affiliation:

• Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.,Iran

Keywords: α-Amylase, α-Glucosidase, Diabetes, Heterocycles, Synthesis, Natural Products.

Abstract: Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently, it has emerged as an important and global health problem with long-term complications and high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes. Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy and α-Gls and were found to be versatile tools for the development of novel anti-diabetic agents.

Cite this article as:

Saeedi Mina, Hadjiakhondi Abbas, Nabavi Mohammad Seyed and Manayi Azadeh, Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors, Current Topics in Medicinal Chemistry 2017; 17(4) . https://dx.doi.org/10.2174/1568026616666160824104655