Abstract
The need for human tissue to aid in organ repair or provide a curative therapy is well known. In this review, we discuss the properties of the epidermal keratinocyte progenitor cell and the biology that underlies the methods that have helped deliver cell therapies to the clinic using this cell type. In addition, we review what the keratinocyte and the dermal fibroblast have taught us about the potential immunogenicity of allogeneic cells. The many observations made using the keratinocyte have broader biological implications and we discuss how this body of work parallels neural stem cell culture and might help us interpret cell behavior in the pancreas.
Keywords: epidermal proliferative unit, keratinocyte progenitor cell, neogenesis neurospheres
Current Neurovascular Research
Title: Progenitor Cell Properties and the Engineering of Tissues
Volume: 1 Issue: 3
Author(s): Janet Hardin-Young and Nancy L. Parenteau
Affiliation:
Keywords: epidermal proliferative unit, keratinocyte progenitor cell, neogenesis neurospheres
Abstract: The need for human tissue to aid in organ repair or provide a curative therapy is well known. In this review, we discuss the properties of the epidermal keratinocyte progenitor cell and the biology that underlies the methods that have helped deliver cell therapies to the clinic using this cell type. In addition, we review what the keratinocyte and the dermal fibroblast have taught us about the potential immunogenicity of allogeneic cells. The many observations made using the keratinocyte have broader biological implications and we discuss how this body of work parallels neural stem cell culture and might help us interpret cell behavior in the pancreas.
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Cite this article as:
Hardin-Young Janet and Parenteau L. Nancy, Progenitor Cell Properties and the Engineering of Tissues, Current Neurovascular Research 2004; 1 (3) . https://dx.doi.org/10.2174/1567202043362360
DOI https://dx.doi.org/10.2174/1567202043362360 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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