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Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Review Article

Smart Inulin-Based Polycationic Nanodevices for siRNA Delivery

Author(s): G. Cavallaro, C. Sardo, C. Scialabba, M. Licciardi and G. Giammona

Volume 14 , Issue 2 , 2017

Page: [224 - 230] Pages: 7

DOI: 10.2174/1567201813666160811145855

Price: $65

Abstract

The advances of short interfering RNA (siRNA) mediated therapy provide a powerful option for the treatment of many diseases by silencing the expression of targeted genes including cancer development and progression. Inulin is a very simple and biocompatible polysaccharide proposed by our groups to produce interesting delivery systems for Nucleic Acid Based Drugs (NABDs), such as siRNA, either as polycations able to give polyplexes and polymeric coatings for nanosystems having a metallic core. In this research field, different functionalizing groups were linked to the inulin backbone with specific aims including oligoamine such as Ethylendiammine (EDA), Diethylediamine (DETA), Spermine, (SPM) etc. In this contribution the main Inulin-based nanodevices for the delivery of siRNA have been reported, analysed and compared with particular reference to their chemical design and structure, biocompatibility, siRNA complexing ability, silencing ability.

Keywords: Biocompatibility, siRNA complexing ability, silencing ability.

Graphical Abstract

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