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Central Nervous System Agents in Medicinal Chemistry


ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

Review Article

How Valid is Placebo in the Indian Setting?

Author(s): Himanshu Sharma* and Bharti Sharma

Volume 17, Issue 2, 2017

Page: [151 - 156] Pages: 6

DOI: 10.2174/1871524916666160810162420

Price: $65


Background: The Placebo is defined as an inert substance with a potent therapeutic effect. Its effect is attributed to its psychological and neurobiological effect. Its use in Psychiatric drug practice, drug trials and clinical practice is common, especially in India. Currently there is a debate whether to use it or not as there are ethical, moral and legal issues. Also, its mechanism of action is not known.

Discussion: The Indian Psychiatry scenario is muddled in relation to use of placebo in Randomized Controlled Trials or Psychiatric clinical practice. Despite the scepticism associated with this phenomenon physicians get influenced by it. The present article focuses on the reviews done so far on the efficacy and use of placebo and also the points in favour and against the same in drug trials and psychiatric clinical practice.

Summary: A number of controversies are associated with this biologically inert substance which has no pharmacological role. Currently in medical sciences many scientific studies have been done solely on placebo. The development in this area may have future implications for further research.

Keywords: Clinical practice, deception, ethics, indian setting, placebo, randomized controlled trials.

Graphical Abstract

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