Synthesis and Herbicidal Activity of Some Novel Pyrazole Derivatives

Title:Synthesis and Herbicidal Activity of Some Novel Pyrazole Derivatives

Volume: 14 Issue: 2

Author(s): Hai-Qin He, Xing-Hai Lie, Jian-Quan Weng and Cheng-Xia Tan

Affiliation:

Keywords: Diacylhydrazine, pyrazole, synthesis, herbicidal activity.

Abstract: Some novel pyrazole derivatives were designed and synthesized through multi-step reactions from substituted phenol as starting material. Their structures were confirmed by ¹H NMR, FTIR, MS and elemental analysis. All these compounds were evaluated their herbicidal activity. The preliminary bioassay results indicated that some of title compounds displayed moderate herbicidal activity at 200 μg/mL. Among them, compounds 4-chloro-N'-(2-(2,5-dimethyl-phenoxy) acetyl)-3-ethyl-1-methyl-1H-pyrazole-5-carbohydrazide, 4-chloro-N'-(2-(2,4-dichlorophenoxy)acetyl)- 3-ethyl-1-methyl-1H-pyrazole-5-carbohydrazide, 4-chloro-3-ethyl-1-methyl-N'-(2-(m-tolyloxy) acetyl)-1H-pyrazole-5-carbohydrazide and 4-chloro-3-ethyl-1-methyl-N'-(2-(3-nitrophenoxy)acetyl)- 1H-pyrazole-5-car-bohydrazide possessed 95%, 100%, 95% and 95% inhibition against Brassica campestris respectively. In the further bioassay, the compound 6l exhibited excellent herbicidal activity either monocotyledon or dicotyledon plant at 150 g/ha.

Cite this article as:

He Hai-Qin, Lie Xing-Hai, Weng Jian-Quan and Tan Cheng-Xia, Synthesis and Herbicidal Activity of Some Novel Pyrazole Derivatives, Letters in Drug Design & Discovery 2017; 14 (2) . https://dx.doi.org/10.2174/1570180813666160805150148