Abstract
This mini-review article provides an overview on the use of magnetic materials for the analysis of protein biomarkers. In particular, the advantage provided by magnetic solid phase extraction will be discussed with selected examples, considering untargeted analysis for screening new biomarker proteins and targeted investigation on known and suggested new biomarkers. Aspects, such as enrichment efficiency over conventional techniques, ease of use, functionalization versatility and automation will be considered, together with quantification and deeper structure elucidation provided by coupling selective or specific enrichment to powerful characterization techniques, such as mass spectrometry.
Keywords: Magnetic beads, magnetic solid phase extraction, protein biomarker, new materials, biomarker enrichment, biomarker quantification.
Current Medicinal Chemistry
Title:Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers
Volume: 24 Issue: 5
Author(s): Susy Piovesana and Anna Laura Capriotti
Affiliation:
- Department of Chemistry, Faculty of Mathematical, Physical and Natural Sciences, Sapienza Università di Roma, P.O. Box: Piazzale Aldo Moro 5, 00185, Rome,Italy
Keywords: Magnetic beads, magnetic solid phase extraction, protein biomarker, new materials, biomarker enrichment, biomarker quantification.
Abstract: This mini-review article provides an overview on the use of magnetic materials for the analysis of protein biomarkers. In particular, the advantage provided by magnetic solid phase extraction will be discussed with selected examples, considering untargeted analysis for screening new biomarker proteins and targeted investigation on known and suggested new biomarkers. Aspects, such as enrichment efficiency over conventional techniques, ease of use, functionalization versatility and automation will be considered, together with quantification and deeper structure elucidation provided by coupling selective or specific enrichment to powerful characterization techniques, such as mass spectrometry.
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Cite this article as:
Piovesana Susy and Capriotti Laura Anna, Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers, Current Medicinal Chemistry 2017; 24(5) . https://dx.doi.org/10.2174/0929867323666160805121905
DOI https://dx.doi.org/10.2174/0929867323666160805121905 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |

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