Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers

Title:Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers

Volume: 24 Issue: 5

Author(s): Susy Piovesana and Anna Laura Capriotti

Affiliation:

• Department of Chemistry, Faculty of Mathematical, Physical and Natural Sciences, Sapienza Università di Roma, P.O. Box: Piazzale Aldo Moro 5, 00185, Rome,Italy

Keywords: Magnetic beads, magnetic solid phase extraction, protein biomarker, new materials, biomarker enrichment, biomarker quantification.

Abstract: This mini-review article provides an overview on the use of magnetic materials for the analysis of protein biomarkers. In particular, the advantage provided by magnetic solid phase extraction will be discussed with selected examples, considering untargeted analysis for screening new biomarker proteins and targeted investigation on known and suggested new biomarkers. Aspects, such as enrichment efficiency over conventional techniques, ease of use, functionalization versatility and automation will be considered, together with quantification and deeper structure elucidation provided by coupling selective or specific enrichment to powerful characterization techniques, such as mass spectrometry.

Cite this article as:

Piovesana Susy and Capriotti Laura Anna, Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers, Current Medicinal Chemistry 2017; 24(5) . https://dx.doi.org/10.2174/0929867323666160805121905