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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Review Article

Putative Mechanisms of Viral Transmission and Molecular Dysregulation of Mammary Epithelial Cells by Human Papillomavirus: Implications for Breast Cancer

Author(s): E. G. de Lima, C. M.M. do Amaral, F. C.Q. Peixe, A. P.A.D. Gurgel, J. da Costa Silva Neto and A. C. de Freitas

Volume 16, Issue 7, 2016

Page: [650 - 659] Pages: 10

DOI: 10.2174/1566524016666160805120410

Price: $65


Breast cancer is the most common cancer in women worldwide. Several studies have demonstrated the presence of Human papillomavirus (HPV) DNA in breast cancer samples. However, the role of HPV in breast carcinogenesis is not clear, and the interaction mechanisms between this infectious agent and the breast cancer cell need to be more fully clarified. In this article, we discuss the putative roles of HPV infection in breast carcinogenesis.

Keywords: Breast cancer, human papillomavirus (HPV), etiological factor, E6 and E7 oncoproteins, HER2, BRCA1, BRCA2.

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