Generic placeholder image

Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Benefits and Limitations of Polymorphic and Amorphous Forms of Active Pharmaceutical Ingredients

Author(s): Alicja Talaczynska, Jakub Dzitko and Judyta Cielecka-Piontek

Volume 22, Issue 32, 2016

Page: [4975 - 4980] Pages: 6

DOI: 10.2174/1381612822666160804100036

Price: $65


Active pharmaceutical ingredients (APIs) can exist in different polymorphic forms as well as in amorphous state. Polymorphic and amorphous forms of APIs can differ in physicochemical properties which in turn can significantly influence their therapeutic safety and effectiveness of the treatment. This review focuses on benefits and limitations of polymorphic and amorphous forms of APIs used in preformulation and formulation studies. Authors present their work on safety precautions for the use of polymorphic and amorphous forms of APIs, analytical techniques used for their identification as well as methods of their preparation especially in regard to limitations of labile APIs.

Keywords: Polymorphs, amorphous form, active pharmaceutical ingredients, solubility, preparation of polymorphic and amorphous forms.

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy