Multicomponent Synthesis of Novel Class of Isatin and 5-isatinyli-denerhodanine Based Diaminofuran Derivatives

Title:Multicomponent Synthesis of Novel Class of Isatin and 5-isatinyli-denerhodanine Based Diaminofuran Derivatives

Volume: 13 Issue: 6

Author(s): Robabeh Baharfar and Somayeh Rassi

Affiliation:

Keywords: 2, 5-diaminofurans, N-(carboxymethyl)isatin, isocynides, dialkyl acetylenedicarboxylates, rhodanine..

Abstract: A simple and efficient method has been developed for the synthesis of a new collection of isatin and 5-isatinylidenerhodanine derivatives carrying furan group, from N-(carboxymethyl)isatin through a multi-component reaction is explained. The reactive 1:1 intermediate formed from the reaction of isocyanides and dialkyl acetylenedicarboxylates was trapped at reflux temperature using N-(carboxymethyl)isatin derivatives to produce poly functionalized furan rings in good yields.

Cite this article as:

Baharfar Robabeh and Rassi Somayeh, Multicomponent Synthesis of Novel Class of Isatin and 5-isatinyli-denerhodanine Based Diaminofuran Derivatives, Letters in Organic Chemistry 2016; 13 (6) . https://dx.doi.org/10.2174/1570178613666160802145006