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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

PEG-SO3H as Eco-friendly Polymeric Catalyst for the Synthesis of 2,3-Dihydroquinazolinones in Water

Author(s): Guoli Huang, Bo Liu, Mingyu Teng and Yegao Chen

Volume 13, Issue 6, 2016

Page: [453 - 458] Pages: 6

DOI: 10.2174/1570178613666160728101809

Price: $65

Abstract

A facile, efficient, green, and environmentally benign method is described for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones by direct cyclocondensation of 2-aminobenzamide with aldehydes or ketones in water using PEG-SO3H as an acidic catalyst under room temperature. This new method totally avoids the use of organic acids, toxic or expensive solvents and affording the corresponding product in good to excellent yields in this reaction.

Keywords: PEG-SO3H, 2, 3-dihydroquinazolinones, water, synthesis.

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