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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article

Role of Methylene Blue in Trauma Neuroprotection and Neuropsychiatric Diseases

Author(s): Mário Márcio Vasconcelos Batista-Filho, Ludmyla Kandratavicius, Emerson Arcoverde Nunes, Vitor Tumas, Benedicto O. Colli, Jaime E.C. Hallak, João Paulo Maia-de-Oliveira and Paulo Roberto B. Evora

Volume 15, Issue 8, 2016

Page: [976 - 986] Pages: 11

DOI: 10.2174/1871527315666160720120326

Price: $65


The prevalence of central nervous system trauma, neurodegenerative and psychiatric diseases has significantly increased in recent years. Most of these diseases show multifactorial causes and several progression mechanisms. The search for a medication which positively interferes in these mechanisms and thereby changes the course of these diseases is of great scientific interest. The aim of the present review is to assess current literature on the possible role of methylene blue (MB) in the central nervous system due to the increasing number of citations in spite of the few articles available on the subject which suggest growing interest in the protective effects of MB on the central nervous system. Searches were performed on PubMed and Thomson Reuters Web of Knowledge. Therefore, we provide an overview of existing articles concerning: 1) MB actions; 2) MB neuroprotection and cardiac arrest; 3) MB neuroprotection and degenerative brain diseases; 4) MB neuroprotection and psychiatric diseases. PubMed was chosen because it holds the highest number of articles on the subject, Thomson Reuters was chosen due to its functionality which evaluates citations through analytic graphs. We conclude that MB has a beneficial effect and acts through many mechanisms and pathways of the central nervous system, being a potential alternative for the treatment of many neurodegenerative and psychiatric diseases.

Keywords: Methylene blue, neuroprotection, neuropsychiatric diseases.

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