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Recent Patents on Inflammation & Allergy Drug Discovery


ISSN (Print): 1872-213X
ISSN (Online): 2212-2710

Research Article

Ursolic Acid and Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inflammatory Activities

Author(s): Dharambir Kashyap, Ajay Sharma, Hardeep S. Tuli, Sandeep Punia and Anil K. Sharma

Volume 10, Issue 1, 2016

Page: [21 - 33] Pages: 13

DOI: 10.2174/1872213X10666160711143904

Price: $65


Background: Plant derived products are not only served as dietary components but also used to treat and prevent the inflammatory associated diseases like cancer. Among the natural products pentacyclic terpenoids including ursolic acid and oleanolic acid are considered as the promising anti-inflammatory therapeutic agents.

Objectives: The current review extensively discusses the anti-inflammatory therapeutic potential of these pentacyclic moieties along with their proposed mechanisms of action. Furthermore, the relevant patents have also been listed to present the health benefits of these promising therapeutic agents to pin down the inflammatory diseases.

Expert opinion: Pentacyclic terpenoids are known to negatively down-regulate a variety of extracellular and intracellular molecular targets associated with disease progression. The major anti-inflammatory effects of these molecules have been found to be mediated via inactivation of NF, STAT3/6, Akt/mTOR pathways. A number of patents on UA & OA based moieties have been reported between 2010 and 2016. Still there have been only a few compounds which meet the need of sufficient hydro solubility and bioavailability along with higher anti-inflammatory activities. Thus, it is essential to develop novel derivatives of terpenpoids which may not only overcome the solubility issues but also may improve their therapeutic effects. In addition, scientific community may utilize nanotechnology based drug delivery systems so as to increase the bio-availability, selectivity and dosages related problems.

Keywords: Chemistry, inflammation, mechanisms, oleanolic acid, patent, ursolic acid.

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