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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Recent Advances on Nitric Oxide in the Upper Airways

Author(s): Mauro Maniscalco, Andrea Bianco, Gennaro Mazzarella and Andrea Motta

Volume 23, Issue 24, 2016

Page: [2736 - 2745] Pages: 10

DOI: 10.2174/0929867323666160627115335

Price: $65


Exhaled nitric oxide (NO) originates from the upper airways, and takes action, to varying extents, in regulation, protection and defense, as well as in noxious processes. Nitric oxide retains important functions in a wide range of physiological and pathophysiological processes of the human body, including vaso-regulation, antimicrobial activity, neurotransmission and respiration. This review article reports the ongoing investigations regarding the source, biology and relevance of NO within upper respiratory tract. In addition, we discuss the role of NO, originating from nasal and paranasal sinuses, in inflammatory disorders such as allergic rhinitis, sinusitis, primary ciliary dyskinesia, and cystic fibrosis.

Keywords: Asthma, Inflammation, humming, PCD, polyposis, nose, sinusitis.

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