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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Spirooxindoles as Potential Pharmacophores

Author(s): Siva S. Panda*, Rachel A. Jones, Praveen Bachawala and Prabhu P. Mohapatra

Volume 17 , Issue 16 , 2017

Page: [1515 - 1536] Pages: 22

DOI: 10.2174/1389557516666160624125108

Price: $65

Abstract

Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.

Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.

This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.

Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

Keywords: Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.

Graphical Abstract

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