Synthesis and Antioxidant Evaluation of Some Novel Benzimidazole Derivatives Containing a Triazole Nucleus

Title:Synthesis and Antioxidant Evaluation of Some Novel Benzimidazole Derivatives Containing a Triazole Nucleus

Volume: 14 Issue: 2

Author(s): Fatih Yılmaz, Emre Menteşe and Nimet Baltaş

Affiliation:

Keywords: 1, 2, 4-triazole, benzimidazole, antioxidant activity, CUPRAC, ABTS, DPPH.

Abstract: Various benzimidazole compounds containing a triazole nucleus were synthesized and screened for their antioxidant activies. The structures of newly synthesized compounds were characterized by ¹H NMR, ¹³C NMR and elemental analysis data. Antioxidant features of the synthesized compounds were investigated by different processes such as 2,2-diphenyl picryl hydrazyl (DPPH),2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and CUPric reducing antioxidant capacity (CUPRAC) methods. Significant antioxidant activity was achieved by some of the synthesized compounds demonstrated as much activity as standards (AA and BHT). Correlation analysis between the CUPRAC antioxidant and ABTS radical scavenging assays revealed positive correlation (R²= 0.926), indicating differing antioxidant activities based on the reaction mechanism

Cite this article as:

Yılmaz Fatih, Menteşe Emre and Baltaş Nimet, Synthesis and Antioxidant Evaluation of Some Novel Benzimidazole Derivatives Containing a Triazole Nucleus, Letters in Drug Design & Discovery 2017; 14 (2) . https://dx.doi.org/10.2174/1570180813666160609082633