Abstract
Glutathione is a thiol-containing tripeptide which composed of glutamic acid, cysteine and glycine. Reduced glutathione possesses the function of anti-oxidation, toxinremoving and other crucial physiological functions. Abnormal level of it indicates the emergence of diseases such as hepatitis, pneumonia, AIDS or even cancer. Therefore real-time detection of it has the important significance of keeping normal physiological condition and monitoring certain diseases. The fluorescence technique has obvious advantages of swift response, high sensitivity and selectivity comparing with other detection methods. The detection of glutathione by fluorescent reagents has attracted much attention. In this review, we summarized fluorescent probes reported so far for glutathione according to the classification of organic and inorganic probes, including coumarin-based probes, BODIPY-based probes, quantum dots-based probes, carbon dots-based probes and so on, focusing on the detection process and mechanism. The review concluded with an outlook towards potential applications of all kinds of probes for glutathione detection.
Keywords: Fluorescent probe, glutathione, detection process, mechanism.
Current Organic Chemistry
Title:Fluorescent Probes for Glutathione Detection
Volume: 20 Issue: 25
Author(s): Juanjuan He, Fanyong Yan, Depeng Kong, Qianghua Ye, Xuguang Zhou and Li Chen
Affiliation:
Keywords: Fluorescent probe, glutathione, detection process, mechanism.
Abstract: Glutathione is a thiol-containing tripeptide which composed of glutamic acid, cysteine and glycine. Reduced glutathione possesses the function of anti-oxidation, toxinremoving and other crucial physiological functions. Abnormal level of it indicates the emergence of diseases such as hepatitis, pneumonia, AIDS or even cancer. Therefore real-time detection of it has the important significance of keeping normal physiological condition and monitoring certain diseases. The fluorescence technique has obvious advantages of swift response, high sensitivity and selectivity comparing with other detection methods. The detection of glutathione by fluorescent reagents has attracted much attention. In this review, we summarized fluorescent probes reported so far for glutathione according to the classification of organic and inorganic probes, including coumarin-based probes, BODIPY-based probes, quantum dots-based probes, carbon dots-based probes and so on, focusing on the detection process and mechanism. The review concluded with an outlook towards potential applications of all kinds of probes for glutathione detection.
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Cite this article as:
He Juanjuan, Yan Fanyong, Kong Depeng, Ye Qianghua, Zhou Xuguang and Chen Li, Fluorescent Probes for Glutathione Detection, Current Organic Chemistry 2016; 20 (25) . https://dx.doi.org/10.2174/1385272820666160602125352
DOI https://dx.doi.org/10.2174/1385272820666160602125352 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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