Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization

Title:Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization

Volume: 17 Issue: 2

Keywords: Indole, Microtubule Polymerization, Anti-tumor, Apoptosis.

Abstract: Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy. Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest among scientists. This review describes the synthesis, bioactivities and SARs of indole-based agents targeting tubulin polymerization during the past decade.

Cite this article as:

Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization, Current Topics in Medicinal Chemistry 2017; 17 (2) . https://dx.doi.org/10.2174/1568026616666160530154812