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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization

Volume 17, Issue 2, 2017

Page: [120 - 137] Pages: 18

DOI: 10.2174/1568026616666160530154812

Price: $65


Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy. Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest among scientists. This review describes the synthesis, bioactivities and SARs of indole-based agents targeting tubulin polymerization during the past decade.

Keywords: Indole, Microtubule Polymerization, Anti-tumor, Apoptosis.

Graphical Abstract

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