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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Isoindole Derivatives: Propitious Anticancer Structural Motifs

Author(s): Richa Kaur Bhatia

Volume 17 , Issue 2 , 2017

Page: [189 - 207] Pages: 19

DOI: 10.2174/1568026616666160530154100

Price: $65

Abstract

Isoindole derivatives constitute an important class of biologically active heterocyclic compounds and continue to attract considerable attention due to their diverse pharmacological profile such as, antimicrobial, anthelmintic, insecticidal, cyclooxygenase isoenzyme (COX-2) and thrombin inhibition with special emphasis on anticancer activity. This review highlights anticancer properties of isoindole derivatives and its related structures and hoping that it would further help in generation of new concepts towards rational design and development of more potent and less toxic anticancer agents.

Keywords: Anti-cancer agents, Isoindole, Isoindoline, Isoindolinone, Phthalimide, Chemotherapy.

Graphical Abstract

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