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Current Cancer Therapy Reviews


ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

YB-1 Activities in Oncogenesis: Transcription and Translation

Author(s): Andreas G. Bader

Volume 2, Issue 1, 2006

Page: [31 - 39] Pages: 9

DOI: 10.2174/157339406775471786

Price: $65


The Y box-binding protein 1 (YB-1) is a multifunctional DNA/RNA-binding protein regulating transcriptional and translational processes. Emerging evidence suggests a role for YB-1 in malignant human disease. Protein expression levels of YB-1 are increased in numerous human cancers, and nuclear YB-1 correlates with poor prognosis of tumor patients. However, YB-1 has also anti-oncogenic activities and interferes with phosphoinositide 3-kinase dependent cellular transformation. The anti-oncogenic activity correlates with cytoplasmic localization and with inhibition of protein synthesis. This review seeks to highlight the transcriptional and translational functions of YB-1 and its role in oncogenesis.

Keywords: Y box, DbpB, p50, NSEP-1, EF-IA, mRNP

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