YB-1 Activities in Oncogenesis: Transcription and Translation

Title: YB-1 Activities in Oncogenesis: Transcription and Translation

Volume: 2 Issue: 1

Author(s): Andreas G. Bader

Affiliation:

Keywords: Y box, DbpB, p50, NSEP-1, EF-IA, mRNP

Abstract: The Y box-binding protein 1 (YB-1) is a multifunctional DNA/RNA-binding protein regulating transcriptional and translational processes. Emerging evidence suggests a role for YB-1 in malignant human disease. Protein expression levels of YB-1 are increased in numerous human cancers, and nuclear YB-1 correlates with poor prognosis of tumor patients. However, YB-1 has also anti-oncogenic activities and interferes with phosphoinositide 3-kinase dependent cellular transformation. The anti-oncogenic activity correlates with cytoplasmic localization and with inhibition of protein synthesis. This review seeks to highlight the transcriptional and translational functions of YB-1 and its role in oncogenesis.

Cite this article as:

Bader G. Andreas, YB-1 Activities in Oncogenesis: Transcription and Translation, Current Cancer Therapy Reviews 2006; 2(1) . https://dx.doi.org/10.2174/157339406775471786