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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Compounds Containing Azole Scaffolds as Cyclooxygenase Inhibitors: A Review

Author(s): Hanan M.A. Ragab, Adnan A. Bekhit, Sherif A.F. Rostom and Alaa El-Din A Bekhit

Volume 16, Issue 30, 2016

Page: [3569 - 3581] Pages: 13

DOI: 10.2174/1568026616666160526125352

Price: $65


There has been considerable interest in azole-containing compounds as promising antiinflammatory agents. Designed compounds with five-membered nitrogen-containing nuclei have demonstrated good anti-inflammatory activity, indicating their potential for the treatment of this highly irritating condition. Pyrazoles, have attracted much more attention than other azoles, however, reports on other azoles demonstrated that they were as effective as pyrazoles. This review describes the different classes of azoles designed as cyclooxygenase inhibitors and the effect of different structural modifications on their activity.

Keywords: Anti-inflammatory agents, Azoles, Imidazoles, Oxadiazoles, Oxazoles, Pyrazoles, Thiazoles, Triazoles.

Graphical Abstract

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