Abstract
It is well known that over the time each species has directed a specific function of its metabolic activity for survival, development and perpetuation, towards a sustained seeking for a balance with the surrounding environment. In this respect, plants became a major point of interest for the pharmaceutical industry due to their capacity of synthetizing organic compounds with specific pharmacological activity, most of them as secondary metabolites. Several major classes of chemical compounds, i.e. flavones, phenolics, terpenoids and essential oils, alkaloids, lectins and polypeptides, and polyacetylenes are phytochemicals with important antimicrobial activity and, besides them, some other natural compounds involved in inter-kingdom communication, such as quorum sensing molecules or natural antimicrobial peptides. These compounds have been proposed as potential alternatives to antibiotics for fighting infectious diseases. Extensive research has been made regarding the antimicrobial efficiency for a plethora of such natural compounds, but, unfortunately, lesser importance has been given to the occurrence of microbial resistance to them. In this respect, our aim was to review the literature, highlighting the latest findings on this topic, for a comprehensive view regarding the risk of using antimicrobials from natural sources in selecting microbial resistance.
Keywords: Microbial resistance, natural compounds, antibiotics.
Graphical Abstract
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
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Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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