Telocytes in Cardiac Protection

Title:Telocytes in Cardiac Protection

Volume: 11 Issue: 5

Author(s): Siyi Fu, Hui Zhu, Siyi Li, Yalong Wang, Yihua Bei and Junjie Xiao

Affiliation:

Keywords: Cardiac telocytes, cardiac protection, cardiac stem cells, angiogenesis, fibrosis, regeneration.

Abstract: Telocytes (TCs) are a distinct type of stromal cells with extremely thin and long prolongations called telopodes (Tps). TCs have been ubiquitously reported in almost all tissues and organs across species including heart. TCs are distinct from fibroblasts as evidenced by ultrastructural characteristics, immunohistochemistry features, gene profiles, proteome features, and miRNA signatures. By means of heterocellular junctions and extracellular vesicles, TCs may be able to regulate cardiac stem cells, angiogenesis, and anti-fibrosis. Therapeutic effects of cardiac TCs in myocardium infarction have been demonstrated. Cardiac TCs could be a source of cardiac repair and protection.

Cite this article as:

Fu Siyi, Zhu Hui, Li Siyi, Wang Yalong, Bei Yihua and Xiao Junjie, Telocytes in Cardiac Protection, Current Stem Cell Research & Therapy 2016; 11(5) . https://dx.doi.org/10.2174/1574888X1105160509234231