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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury

Author(s): R. Kingston, C. J. Kelly and P. Murray

Volume 10, Issue 19, 2004

Page: [2401 - 2410] Pages: 10

DOI: 10.2174/1381612043384015

Price: $65


As a non-toxic endogenous antioxidant, the semi-essential amino acid taurine is a potential attenuator of oxidative damage such as that produced by ischaemia-reperfusion injury. Ischaemia-reperfusion injury is a well established if paradoxical phenomenon whereby ischaemic tissue, doomed to necrosis if it is not reperfused, is actually further damaged by oxidative attack when perfusion is restored. This paper is a review of the literature concerning therapeutic strategies in ischaemia-reperfusion injury, including nonpharmacological and pharmacological interventions. There is consistent experimental evidence of an important role of taurine in ischaemia-reperfusion injury, with a clinical role emerging in human trials of taurine administered prior to coronary artery bypass grafting and heart valve surgery.

Keywords: antioxidants, ischaemia-reperfusion injury, lipid peroxidation, oxidative stress, reperfusion, taurine

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