Abstract
The contribution of small molecular weight chemoattractant cytokines (chemokines) and their receptors in the trafficking of tumor, immune and vascular cells pertaining to the development and progression of cancer has begun to be investigated. The current literature indicates that interactions between the immune network, angiogenic and cell survival cascades are important for the trafficking and progression of human cancer and that chemokines and chemokine receptors play a central role in these complex inter-related pathways. Several therapeutic approaches have been reviewed and suggest that the most promising arise from the development of combinations of chemokine receptor antagonists.
Keywords: chemokine receptors, cancer, chemoattractant cytokines, chemokine receptor antagonists
Current Pharmaceutical Design
Title: An Expanding Appreciation of the Role Chemokine Receptors Play in Cancer Progression
Volume: 10 Issue: 19
Author(s): O.M. Zack Howard and Carole L. Galligan
Affiliation:
Keywords: chemokine receptors, cancer, chemoattractant cytokines, chemokine receptor antagonists
Abstract: The contribution of small molecular weight chemoattractant cytokines (chemokines) and their receptors in the trafficking of tumor, immune and vascular cells pertaining to the development and progression of cancer has begun to be investigated. The current literature indicates that interactions between the immune network, angiogenic and cell survival cascades are important for the trafficking and progression of human cancer and that chemokines and chemokine receptors play a central role in these complex inter-related pathways. Several therapeutic approaches have been reviewed and suggest that the most promising arise from the development of combinations of chemokine receptor antagonists.
Export Options
About this article
Cite this article as:
Howard Zack O.M. and Galligan L. Carole, An Expanding Appreciation of the Role Chemokine Receptors Play in Cancer Progression, Current Pharmaceutical Design 2004; 10 (19) . https://dx.doi.org/10.2174/1381612043383935
| DOI https://dx.doi.org/10.2174/1381612043383935 |
Print ISSN 1381-6128 |
| Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Multidisciplinary Pharmaceutical Drug Design Strategies in the Progress of Drug Discovery"
The process of developing a drug is time and money-consuming, but also fascinating. The development of numerous computational techniques, synthetic methodologies, formulation-based drug discovery, etc., has improved the drug discovery process. The process of developing new drugs is significantly hampered by drug-poor pharmacodynamics and pharmacokinetic problems. To address these challenges, ...read more
Accelerating Cancer drug discovery using Artificial intelligence and In Silico methods
The Artificial intelligence and in silico methods speed up cancer drug discovery, transforming how new treatments are developed. Artificial intelligence, along with in silico methods, allows for quick investigation of large biological datasets, helping identify potential drug targets with remarkable speed and accuracy. Machine learning models help us understand how ...read more
Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.
This thematic issue will emphasize the recent breakthroughs in the mechanisms of Inflammatory bowel disease (IBD) pathogenesis and devotes some understanding of both Crohn’s and ulcerative colitis. It is expected to include studies about cellular and genetic aspects, which help to precipitate the disease, and the immune system-gut microbiome relations ...read more
Artificial Intelligence and Computational Approaches in Drug Discovery
Computer-aided drug design (CADD) and artificial intelligence (AI) are fundamentally reshaping drug discovery pipelines by significantly enhancing efficiency in molecular screening, rational drug design, and natural product development. In the field of molecular screening, the integration of virtual high-throughput screening with advanced AI models enables rapid analysis of million-compound libraries, ...read more
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Radiation Bystander Effect and its Potential Implications for Human Health
Current Molecular Medicine Targeting Heat Shock Protein 90 for Malaria
Mini-Reviews in Medicinal Chemistry Regulation of Mesenchymal Phenotype by MicroRNAs in Cancer
Current Cancer Drug Targets QSAR Study of PARP Inhibitors by GA-MLR, GA-SVM and GA-ANN Approaches
Current Analytical Chemistry Multiple Functions of Mammalian Germinal Center Kinases
Current Chemical Biology Editorial [Hot Topic: ABC Transporters: Role in Modulation of Drug Pharmacokinetics and in Physiopathology and Therapeutic Perspectives (Guest Editor: Francoise Van Bambeke)]
Current Drug Targets STAT Signaling and Cell Function
Current Genomics Bioactive Polyphenols from Healthy Diets and Forest Biomass
Current Nutrition & Food Science Fractal Analysis of the Bone Marrow in Myelodysplastic Syndromes
Current Bioinformatics New Use for Old Drugs? Prospective Targets of Chloroquines in Cancer Therapy
Current Drug Targets PI-3-Kinase Inhibitors in Colorectal Cancer
Current Cancer Drug Targets Pleiotropic Functions of Rho GTPase Signaling: A Trojan Horse or Achilles Heel for Breast Cancer Treatment?
Current Drug Targets Radiosynthesis of N.C.A. Sodium [18F]Fluoroacetate and Radiopharmacological Characterization in Rats and Tumor-Xenografted Mice
Current Radiopharmaceuticals Role of the Retinoblastoma Tumor Suppressor in the Maintenance of Genome Integrity
Current Molecular Medicine Evolution of the Strategies for Screening and Identifying Human Tumor Antigens
Current Protein & Peptide Science ANN and Bayesian Classification Models for Virtual Screening of Endocrine-Disrupting Chemicals
Combinatorial Chemistry & High Throughput Screening Bioactive Proteins and Peptides from Soybeans
Recent Patents on Food, Nutrition & Agriculture Analysis the Effectiveness of Oral Massage Using Sono-elastography
Neuroscience and Biomedical Engineering (Discontinued) E2F1-Mediated Apoptosis as a Target of Cancer Therapy
Current Molecular Pharmacology Biology of Tenascin C and its Role in Physiology and Pathology
Current Medicinal Chemistry





