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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Research Article

Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

Author(s): Mahesh A. Barmade, Prashant R. Murumkar, Mayank Kumar Sharma and Mange Ram Yadav

Volume 16, Issue 26, 2016

Page: [2863 - 2883] Pages: 21

DOI: 10.2174/1568026616666160506145700

Price: $65


Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.

Keywords: Anticancer agents, Antidepressant agents, Antidiabetic agents, Antimicrobial agents, Benz-isoxazole, Fused isoxazole, Isoxazole, Tricyclic isoxazole.

Graphical Abstract

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