Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

Title:Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

Volume: 16 Issue: 26

Author(s): Mahesh A. Barmade, Prashant R. Murumkar, Mayank Kumar Sharma and Mange Ram Yadav

Affiliation:

Keywords: Anticancer agents, Antidepressant agents, Antidiabetic agents, Antimicrobial agents, Benz-isoxazole, Fused isoxazole, Isoxazole, Tricyclic isoxazole.

Abstract: Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.

Cite this article as:

Barmade A. Mahesh, Murumkar R. Prashant, Sharma Kumar Mayank and Yadav Ram Mange, Medicinal Chemistry Perspective of Fused Isoxazole Derivatives, Current Topics in Medicinal Chemistry 2016; 16(26) . https://dx.doi.org/10.2174/1568026616666160506145700