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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Matrine: Bioactivities and Structural Modifications

Author(s): Jiulin Huang and Hui Xu

Volume 16 , Issue 28 , 2016

Page: [3365 - 3378] Pages: 14

DOI: 10.2174/1568026616666160506131012

Price: $65


Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity, insecticidal activity, antimicrobial activity, etc. The present review has summarized the biological activities and structural modifications of matrine and its derivatives focused on their N-1 position and lactam ring from 2010 to 2015. In addition, the mechanism of action and structure-activity relationships of matrine and its derivatives are discussed.

Keywords: Matrine derivatives, Biological activities, Structural modifications, Mechanism of action, Structure-activity relationship, Sophora flavescens.

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