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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Exploring Pyrimidine Pharmacophore as Thymidine Monophosphate Kinase Inhibitors for Antitubercular Activity: A Review

Author(s): Trupti Sameer Chitre, Kalyani Dhirendra Asgaonkar, Shital Manoj Patil, Muthu Kumaradoss Kathiravan and Subhash Balkrishna Padhye

Volume 16 , Issue 28 , 2016

Page: [3211 - 3223] Pages: 13

DOI: 10.2174/1568026616666160506130914

Price: $65

Abstract

Tuberculosis (TB) has been declared as a health emergency due to emergence of resistant strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the current situation necessitates developing new antitubercular agents acting on novel targets for effectively controlling TB. Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target, which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs reported as TMPKmt inhibitors.

Keywords: Tuberculosis, Thymidine Monophoshate Kinase (TMPKmt) inhibitors, Nucleotide, Nucleoside, Pyrimidine.

Graphical Abstract

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