Abstract
Usage of excipients from natural sources is now the most attractive research areas. Most of the synthetic polymers used in the formulation are detrimental to some extent for the human physiological system. Herbal substitute will be the best choice to minimize long term adverse effect. The purposes of repeated dose toxicity testing are to obtain information about biologic activity of chemicals. In the present study, repeated oral toxicity study of formulation containing metformin 1000mg and sitagliptin 50mg in Swiss albino rats was studied. Microwave assisted acrylamide grafted C. tora is used as a polymer in the formulation.
Rats of both sexes from control and different dose groups (100, 200 and 400 mg/Kg body wt.) exhibited normal body weight gain throughout dosing period. Study protocol was prior approved by animal ethics committee. Combination treatment for 28 days, formulation did not show any significant features of haematological, behavioural, hepatotoxicity and nephrotoxicity in rats. Therefore it can be concluded that the combination using the grafted polymer is safe in these repeated doses in rats.
Keywords: Metformin, sitagliptin, toxicity, Grafted Cassia tora, swiss albino rats.
The Natural Products Journal
Title:Repeated dose Toxicity Study in Rats of the Formulation Containing Metformin and Sitagliptin using Microwave Assisted Acrylamide Grafted Cassia tora as Polymer
Volume: 6 Issue: 2
Author(s): Shubhasis Dan, Nilendra Chatterjee, Pallab Mandal, Anjan Das, Balaram Ghosh and Tapan Kumar Pal
Affiliation:
Keywords: Metformin, sitagliptin, toxicity, Grafted Cassia tora, swiss albino rats.
Abstract: Usage of excipients from natural sources is now the most attractive research areas. Most of the synthetic polymers used in the formulation are detrimental to some extent for the human physiological system. Herbal substitute will be the best choice to minimize long term adverse effect. The purposes of repeated dose toxicity testing are to obtain information about biologic activity of chemicals. In the present study, repeated oral toxicity study of formulation containing metformin 1000mg and sitagliptin 50mg in Swiss albino rats was studied. Microwave assisted acrylamide grafted C. tora is used as a polymer in the formulation.
Rats of both sexes from control and different dose groups (100, 200 and 400 mg/Kg body wt.) exhibited normal body weight gain throughout dosing period. Study protocol was prior approved by animal ethics committee. Combination treatment for 28 days, formulation did not show any significant features of haematological, behavioural, hepatotoxicity and nephrotoxicity in rats. Therefore it can be concluded that the combination using the grafted polymer is safe in these repeated doses in rats.
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Cite this article as:
Dan Shubhasis, Chatterjee Nilendra, Mandal Pallab, Das Anjan, Ghosh Balaram and Kumar Pal Tapan, Repeated dose Toxicity Study in Rats of the Formulation Containing Metformin and Sitagliptin using Microwave Assisted Acrylamide Grafted Cassia tora as Polymer, The Natural Products Journal 2016; 6 (2) . https://dx.doi.org/10.2174/2210315506666160503163018
DOI https://dx.doi.org/10.2174/2210315506666160503163018 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
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