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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Research Article

Biological Activities of Salvia santolinifolia Boiss. A Multifunctional Medicinal Plant

Author(s): Mir Babak Bahadori, Hassan Valizadeh, Behvar Asghari, Leila Dinparast, Shahram Bahadori and Mahdi Moridi Farimani

Volume 12, Issue 4, 2016

Page: [297 - 305] Pages: 9

DOI: 10.2174/1573407212666160426161112

Price: $65


Background: Salvia species are used traditionally for treatment of many disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, hemorrhoids and diarrhea.

Methods: In this study, antibacterial, antioxidant, toxicity, acetylcholinesterase and - glucosidase inhibitory activities of several extracts of S. santolinifolia were evaluated. Total phenol and flavonoid contents of the extracts were also determined.

Results: The MeOH extract showed high antioxidant activity in DPPH scavenging and ferric reducing power assays. All samples exhibited high acetylcholinesterase (IC50 = 42-89 g/ml) and -glucosidase inhibitory activities (IC50 = 24-174 g/ml). The MeOH extract showed great antibacterial and antifungal activities especially against Bacillus cereus and Candida albicans with MIC values from 10 to 200 g/ml.

Conclusion: Our findings indicated that S. santolinifolia is a rich source of natural compounds with strong antimicrobial, antidiabetic and anti-Alzheimer activities. This plant has great potential for several applications as pharmaceuticals and functional foods.

Keywords: Salvia, diabetes mellitus, alzheimer, antioxidant, antimicrobial, phenolic compounds.

Graphical Abstract

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