Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Pyridine Based Antitumour Compounds Acting at the Colchicine Site

Author(s): R. Álvarez, L. Aramburu, P. Puebla, E. Caballero, M. González, A. Vicente, M. Medarde and R. Peláez

Volume 23 , Issue 11 , 2016

Page: [1100 - 1130] Pages: 31

DOI: 10.2174/092986732311160420104823

Price: $65

Abstract

Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharmacokinetic and pharmacodynamics properties. CSL have been classified according to their chemical structures and the chemical structures of the pyridine and azine containing antimitotic compounds are described. The designed principles behind the structural modifications and the achieved effect on the biological activity upon inclusion of these heterocycles are also discussed. Lessons from the achievements and failures have been extracted and future perspectives delineated.

Keywords: Pyridine, azines, antimitotics, tubulin, colchicine, antitumour, drug design.


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy