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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Research Article

Poly(ADP-Ribose) Polymerases in Aging – Friend or Foe?

Author(s): András Vida, Omar Abdul-Rahman, Edit Mikó, Attila Brunyánszki and Peter Bai

Volume 17, Issue 7, 2016

Page: [705 - 712] Pages: 8

DOI: 10.2174/1389203717666160419144959

Price: $65

Abstract

Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.

Keywords: PARPs, mitochondria, DNA repair, aging, healthspan, energy stress.

Graphical Abstract

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