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Recent Patents on Anti-Cancer Drug Discovery


ISSN (Print): 1574-8928
ISSN (Online): 2212-3970

Review Article

Mitochondrial Biogenesis Inhibitors for Anticancer Therapy: A Review of Recent Patents

Author(s): Jinzheng Wang, Xiaoan Wen, Jun Liu and Hongbin Sun

Volume 11, Issue 3, 2016

Page: [332 - 341] Pages: 10

DOI: 10.2174/1574892811666160418123628

Price: $65


Recent studies show that enhanced mitochondrial biogenesis can “fuel” the cancer cells to grow and migrate. It is therefore proposed that inhibiting the mitochondrial biogenesis could be a new approach to cancer therapy. This review summarizes recent patents and papers in the development of small molecule inhibitors of key regulators responsible for tumor mitochondrial biogenesis, including PPARγcoactivator-1α(PGC-1α), PPARγcoactivator-1β, estrogen-related receptor family (ERRs), estrogen receptor α(ERα), mammalian target of rapamycin, c-Myc and PPARs.

Keywords: Cancer, energy metabolism, inhibitors, mitochondrial biogenesis, PGC-1α, tumor migration.

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